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Katragkou, Eleni

Inscriptions Ptolemaic and Roman Egypt

Savvopoulos, Kyriakos (2018)

Inscribed monuments in Greek, Latin and Egyptian, from Roman Egypt

Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations

Leontiadou, Hari; Galdadas, Ioannis; Cournia, Zoe

The kinase PI3Ka is involved in fundamental cellular processes such as cell proliferation and differentiation and is frequently mutated in human malignancies. One of the most common mutations is E545K, which ...

Investigating the effect of RXRa S427F mutant on RXRa tetramers

Cournia, Zoe; Galdadas, Ioannis

Retinoid X nuclear receptors (RXRs) are ligand-dependent transcriptional modulators that execute their biological action through the generation of functional heterodimers. Biochemical data indicate that, in the absence of ...

Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant

Cournia, Zoe; Gkeka, Paraskevi

The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110a the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Ka which activates signaling cascades leading to cell ...

Marble Sculpture

Naes, Maram (2018)

XRF and FTIR analysis of Marble sculptural samples from Nabataean Petra

Metal-Organic Frameworks as drug delivery systems: The case of IRMOF-74-III and gemcitabine studied by MD simulations

Cournia, Zoe; Galdadas, Ioannis (BRFAA, 2017-04-27)

A multiscale computational study is reported that investigates the microscopic behavior of the anti-cancer drug gemcitabine (GEM) stored in metal organic frameworks IRMOF-74-III and the functionalized OH-IRMOF-74-III. ...

Molecular Dynamics simulations of lysozyme in water

Cournia, Zoe (BRFAA, 2015-05-02)

The main objective of this practical is to provide an overview of classical Molecu- lar Dynamics (MD) simulations and Normal Mode Analysis (NMA) by examining the protein Lysozyme within the framework of the NAMD program.