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    Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant 

    Cournia, Zoe; Gkeka, Paraskevi
    The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110a the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Ka which activates signaling cascades leading to cell ...
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    Exploring a Non-ATP Pocket for Potential Allosteric Modulation of PI3Kα 

    Cournia, Zoe; Gkeka, Paraskevi
    Allosteric modulators offer a novel approach for kinase inhibition because they target less conserved binding sites compared to the active site; thus, higher selectivity may be obtained. PIK-108, a known pan phosphoinositide ...

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    Author
    Cournia, Zoe (2)
    Gkeka, Paraskevi (2)Subject
    cancer, PI3Ka, PI3K alpha, Molecular Dynamics simulations, mutation, H1047R, oncogene, breast cancer (2)
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