The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110a the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Ka which activates signaling cascades leading to cell ...

Allosteric modulators offer a novel approach for kinase inhibition because they target less conserved binding sites compared to the active site; thus, higher selectivity may be obtained. PIK-108, a known pan phosphoinositide ...