Browsing PI3Ka by Title
Now showing items 2-3 of 3
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Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
The kinase PI3Ka is involved in fundamental cellular processes such as cell proliferation and differentiation and is frequently mutated in human malignancies. One of the most common mutations is E545K, which ... -
Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant
The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110a the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Ka which activates signaling cascades leading to cell ...