Browsing PI3Ka by Subject "cancer, PI3Ka, PI3K alpha, Molecular Dynamics simulations, mutation, E545K, oncogene, breast cancer"
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Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
The kinase PI3Ka is involved in fundamental cellular processes such as cell proliferation and differentiation and is frequently mutated in human malignancies. One of the most common mutations is E545K, which ...